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251 When the GLP-1 analogue liraglutide was administered to patients with psoriasis (an inflammatory disease associated with obesity and diabetes) this led to a decreased psoriasis area severity index, and cytokine secretion was decreased from natural killer cells in a glycaemic control-independent manner

Your body needs time to adjust to each: GLP-1 receptor: Slows gastric emptying, reduces appetite GIP receptor: Enhances insulin signaling, affects fat metabolism Glucagon receptor: Increases energy expenditure, promotes fat oxidation Jumping to high doses overwhelms these systems, causing: Severe nausea and vomiting Treatment discontinuation Longer overall time to reach therapeutic doses The data: In the Phase 2 NEJM study, participants who started at 4 mg instead of 2 mg had significantly higher rates of gastrointestinal side effects

According to altRx, these clinicians retain sole discretion over whether to prescribe

Our goal is to ensure that every patient has access to a weight loss program that aligns with their goals and financial circumstances