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People ask me all the time whether these compounded drugs are an option because of the cost and access, said Michael Blyumin, PharmD, an ambulatory clinical care pharmacist at Stanford Medicine

Current clinical trials data suggest that retatrutide is a safe and effective medication with manageable side effects

Microdosing is theoretically safer because the dose is lower

Orforglipron also surpassed oral semaglutide in terms of weight loss: 36-milligram doses of Eli Lillys drug resulted in an average of 8 percent body-weight reduction (nearly 20 pounds) compared with 5 percent weight loss (11 pounds) in participants who took 14 mg of oral semaglutide