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Moreover, a recent report demonstrated significantly reduced mitochondrial DNA (mtDNA) copy numbers in cumulusoocyte complexes from PCOS women, accompanied by increased oxidative modifications of mtDNA, confirming that mitochondrial integrity within the gamete microenvironment is severely compromised (61)

For most people living sedentary or moderately active lives, the body's natural glutathione production keeps pace with demand

On the contrary, GPX4 was not a target of SCLA4, which induced senolysis by apoptosis (Fig

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