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While injectable options offer slightly higher efficacy and established cardiovascular benefits, oral therapies provide a valuable alternative for patients who prefer non-invasive treatment

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The choice of antihyperglycaemic treatment is usually based on comorbidities, baseline cardiovascular risk, side effects, cost and clinical assumptions, but rarely on measurements of pathophysiological features driving the deteriorating metabolic state that ultimately leads to complications 2

Diabetic nephropathy: An FDA decision for semaglutide (Ozempic) for the prevention of diabetic nephropathy in adults with T2DM and cardiovascular disease (CVD) is expected in January 2025