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Most patients benefit from injections every few weeks, depending on their deficiency level

doi: 10.1159/000472149 118 MahilSKMcSweeneySMKloczkoEMcGowanBBarkerJNSmithCH

In addition to these factors, aging and obesity are also considered as endogenous risk factors

Components of energy balance and weight loss IF typically leads to a reduction in energy intake (Reference Cienfuegos, Gabel and Kalam5,Reference Trepanowski, Kroeger and Barnosky6,Reference Clayton, Stensel and James21,Reference Varady, Bhutani and Klempel34,Reference Betts, Richardson and Chowdhury40,Reference Clayton, Barutcu and Machin42,Reference Gabel, Hoddy and Haggerty68) , which is likely the reason for weight loss, and current evidence suggests this is one of the primary mechanisms responsible for improvements in metabolic health (Reference Varady, Cienfuegos and Ezpeleta3)