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The jump from placebo to 1mg represents GLP-1 and partial GIP activation

Diet quality matters significantly toopatients who reduce processed foods and added sugars typically see faster and more substantial results than those making minimal dietary changes

Using the clinical trial escalation protocol (2mg starting dose with 2mg increases every 4 weeks), reaching the 12mg maintenance dose takes approximately 20 weeks

As depicted in Figures 1AC, cholesterol stimulation inhibited the cell viability, promoted cell apoptosis, and decreased the protein levels of ABCA1 in a concentration-dependent manner, indicating the occurrence of cholesterol-induced toxicity in INS-1 cells