health canada approval zepbound tirzepatide obesity canada date F.D.A. Approves New Drug That Will Compete With Wegovy Zepbound (Mounjaro/Tirzepatide) for weight management

Although previous ex vivo studies employing NCI-H716 cells (a human L cell line) [35] or human ileal and colonic tissues [14] were indicative of a direct effect of metformin in stimulating GLP-1 release, clinical evidence suggests that the augmentation of postprandial GLP-1 secretion by metformin is largely indirect

One emerging strategy in diabetes management is the use of retatrutide, a novel medication that has shown promise in effectively controlling blood sugar levels

Mondrguez-Gonzlez, S

However, the dose reduction of SU and/or insulin should be in cautious stepwise fashion to avoid diabetic ketoacidosis, as per the drug safety update from the Medicines and Healthcare products Regulatory Agency [88]