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In the Phase 2 obesity trial (NEJM, 2023), participants were assigned to different dose arms with varying escalation schedules

Tirzepatide, used in Zepbound and Mounjaro, targets both the GLP-1 and the GIP receptor agonist, while semaglutide, found in Wegovy and Ozempic, mimics only the GLP-1 receptor agonist, a type of hormone in the body that impacts everything from the brain to muscle to the pancreas, stomach and liver

The gut microbiome's role in GLP-1 regulation is an active area of research, with emerging evidence suggesting that microbial diversity and specific bacterial strains may influence incretin hormone secretion, but more human studies are needed to establish clinical significance

Compounded injectable GLP-1s typically come in multi-dose vials - you draw the dose yourself using a syringe