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It is notable that even if the pathway is absent, ascorbate is present in some of these compartments, albeit in more oxidised form (Conklin et al

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Ophthalmological conditions and other optic neuropathies are more common with age, meaning these need to be distinguished from subclinical involvement of the optic nerve in MS in older people 48

Clinical data from weight-loss medication trials shows that patients drinking at least 2.53 liters (1012 cups) daily experience constipation rates 40% lower than those drinking less than 1.5 liters