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Common digestive MTHFR symptoms include: IBS (Irritable Bowel Syndrome) alternating constipation and diarrhea, cramping, or abdominal pain Chronic bloating and gas feeling uncomfortable or distended after meals Food sensitivities and intolerances reactions to gluten, dairy, histamine-rich foods, or FODMAPs Leaky gut syndrome increased intestinal permeability leading to systemic inflammation Nausea or acid reflux particularly after eating certain foods Nutrient malabsorption low B12, folate, or iron despite adequate dietary intake Why this happens: Methylation supports detoxification pathways in the liver and helps break down histamine

In a longitudinal study ( n = 117) of post-bariatric surgery liraglutide at the higher dose of 3.0 mg, patients had significant weight loss irrespective of initial surgery (RYGB 7.1 8.7 kg, LAGB: 6.0 7.2 kg, LSG: 4.5 3.5) [41]

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So, regulation of endocan is one of the ways that can prevent vascularization