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Notably, knockdown of Gdh1 in different mouse cell lines (HepaMP9-1, 3T3 and KL-155) did not alter AMPK expression (Extended Data Fig

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Solving this dosing equation during development is critical to ensure efficacy is not limited during trials an outcome that could jeopardise the chances of approval

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Other barrier components include phospholipids within the mucosal surface, epithelial factors including tight junctions, the intestinal immune system including lymphocytes and the gut microbiota [4,68]

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