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The minor increase in side effect risk from one-day-early dosing is far less consequential than the cascade of problems from a missed dose

Annu Rev Physiol (2016) 78:27799.10.1146/annurev-physiol-021115-105439 20 NakamuraEHasumuraMUneyamaHToriiK

Nature 304 (5924), 368371

If you have taken a compound sourced outside of licensed channels and experienced side effects, you are strongly encouraged to report this via the MHRA's Yellow Card scheme at yellowcard.mhra.gov.uk