In addition to the relevance of POP conjugation cited previously, hyperglycemia and hyperinsulinemia appear to directly inhibit glutathione synthesis (GCL), and the increased production of reactive oxygen species which accompanies diabetes further depletes GSH levels
, 591 , 924-933, doi: Fan, D., Lin, X., Zhang, F., Zhong, W., Hu, J., Chen, Y., Cai, Z., Zou, Y., He, X., Chen, X., Lan, P., and Wu, X
Studies have shown that myricetin significantly increased the activity of the Nrf2/HO-1 pathway to enhance the resistance to oxidative stress, demonstrated the reversal of glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities, and reduced malondialdehyde (MDA) production [110]
It can be taken orally or applied transdermally for targeted effects