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3.3 Fat Metabolism While Hexarelin is not a metabolic peptide in the same class as Semaglutide or Tirzepatide, elevated GH/IGF-1 signaling drives: Increased lipolysis (fat breakdown) Enhanced fatty acid oxidation Reduction in visceral adipose tissue Tesamorelin, an FDA-approved GHRH analog, received approval specifically for visceral fat reduction demonstrating that GH-axis stimulation has meaningful metabolic effects