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Investigators have studied the compound in combination with other research molecules, in biomaterial-integrated delivery formats, and in cell-type-specific contexts that broaden the mechanism understanding documented in foundational papers

Synaptic biomarkers, or proteins found in cerebral spinal fluid, have been found to be linked to early indicators of Alzheimer's disease progression in a study that observed over 700 people: Biomarkers linked to excitatory neuron communication, specifically Neuronal Pentraxin (NPTX2), were observed at low levels to determine correlation

Mikus, D., Grabarevic, Z., Rucman, R., Petek, M., Turkovic, B., Rokotov, D

It was first described in the scientific literature in 1993 by Sikiri and colleagues