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The nerves are generating sensory reports without appropriate external stimuli

Human evidence - Phase 3 TRIUMPH-4 (Eli Lilly, December 11, 2025) Adults with obesity and knee osteoarthritis

This dual action on glucose metabolism and satiety explains its efficacy in both diabetes management and weight reduction

These include a body mass index (BMI) of 35 kg/m or above (or 32.5 kg/m or above for people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean backgrounds) with at least one weight-related comorbidity, and previous unsuccessful attempts at weight loss through diet and exercise