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GHK-Cu is investigated in preclinical and dermatological research for its effects on collagen and glycosaminoglycan synthesis, fibroblast activation, angiogenesis, copper-dependent enzyme function, antioxidant pathways, and DNA repair gene expression

Previous research has established that VDR is expressed in endothelial cells, vascular smooth muscle cells, and macrophages within the vascular wall being involved in involved in vascular homeostasis [13, 47]