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These findings, along with indications of safety and potential benefits for PAD outcomes, suggest that GLP-1RAs could be considered a preferred therapy over other anti-diabetic medications for patients with concurrent T2DM and PAD [79]

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The mechanistic contrast matters clinically: a satiety-hormone agonist and a central stimulant produce different side-effect profiles, different cardiovascular considerations, and different rules about how long a patient can stay on the drug