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Fe 3+ is then reduced to Fe 2+ by six-transmembrane epithelial antigen of the prostate 3 (STEAP3), and Fe 2+ is then stored in the unstable iron pool (LIP) and ferritin, which is mediated by divalent metal transporter 1 (DMT1) or Zinc-Iron regulatory protein family 8/14 (ZIP8/14)

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Patients should be directed toward evidence-based alternatives for metabolic optimization