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in general, there is no obvious predisposing cause (Thijs et al., 2019)

Furthermore, compared with patients who received radiotherapy alone, breast cancer patients who underwent CR concurrently with radiotherapy exhibited a significant reduction in the serum levels of immunosuppressive cytokines, suggesting potential benefits of CR in mitigating radiation-induced immunosuppression

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Notably, identical lactate concentrations exert diametrically contrasting effects on ferroptosis susceptibility in malignant lung cancer cells compared with their normal epithelial counterparts, highlighting fundamental differences in lactate metabolism between these cellular contexts (82,99)