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Moreover, multiple in vitro (64,65) and in vivo (66,67) studies suggest that ergothioneine activates the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), which triggers the cellular antioxidant defence system

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Given its significance, Glutathione IV therapy has garnered attention as a means to directly replenish this vital molecule, particularly as it is not as effectively absorbed through oral supplementation

Under these circumstances, it has been shown that astroglia releases TNF-, followed by a release of glutamate while also activating microglia [48]