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Galagan JE, Calvo SE, Cuomo C, Ma LJ, Wortman JR, et al

4a) and found that ferroptosis was among the top 20 enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways (Fig

Specifically, attenuation of MAPK pathway activation may contribute to the reduction of inflammatory and stress responses following irradiation, whereas regulation of Rap1-associated signaling may be involved in the maintenance of adherens junction-related proteins, including -catenin and E-cadherin, thereby supporting intestinal barrier integrity

However, our data suggest that such inhibitors may have more utility when given in combination with 5FU-based chemotherapy