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One potential mechanism is the Nrf2-ARE pathway, which induces a phase 2 detoxification response that promotes disruption of Nrf2-Keap protein interactions, translocation of Nrf2 to the nucleus, and regulation of target gene expression through the ARE, enhancing cellular defense against oxidative damage (Sharma et al., 2010)

DA is a strong modulator of prefrontal activity and increases excitability of pyramidal cells in response to depolarization via D1 receptors [101]

With consistent use, it can help: Reduce dark spots and hyperpigmentation Brighten overall complexion Support even skin tone This is especially beneficial for individuals dealing with acne scars, melasma, or sun damage

Cross-sectional evaluations involving clinical assessment and multimodal neuroimaging were conducted across all groups (Supplementary Fig