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Like oxyntomodulin, exendin-4 exhibits more transient interactions than GLP-1 with residues at the base of the peptide binding cavity, albeit it that the pattern of interactions with the polar core are relatively conserved

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Additionally, fermentable fibers (called prebiotics) release not only GLP-1, but also another key hormone that decreases your appetite, called peptide YY (PYY) (Parnell, et al., 2012)