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The primary endpoint was the overall percent use and change in use over time of GIP/GLP-1 RA, while secondary endpoints included demographic and clinical factors associated with medication use

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The cryo-EM map for the oxyntomodulin-bound complex enabled robust modelling and confident assignment of most of the side-chain rotamers for oxyntomodulin, the G protein and the receptor TMD (Supplementary Fig

Glatter: In practice, many patients labeled non-responders to GLP-1 therapy are experiencing incomplete dosing, early discontinuation because of gastrointestinal side effects, insufficient treatment duration, or competing metabolic drivers such as severe insulin resistance, sleep disruption, sarcopenia, or medication-associated weight gain