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Enteroendocrine cells (EECs), the microbiota, and metabolites produced by the microbiota constitute a complex signaling system [13] that involves the enteric plexus, CNS afferents and efferents, and the modulation of numerous brain nuclei like the nucleus tractus solitarius, hypothalamus, thalamus, and many others directly involved in the control of glucose and energy homeostasis [14]

Semaglutide helps manage blood sugar levels by mimicking a hormone called GLP-1 (glucagon-like peptide-1)

You may experience nausea/vomiting, diarrhea or constipation, skin rash at injection site Difference between GLP-1 and Combination of GLP-1 and GIP Mechanism of Action: GLP-1: A GLP-1 receptor agonist that enhances insulin secretion, reduces appetite, and slows gastric emptying