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Also at synapses distant from those stimulated during the induction, heterosynaptic plasticity is often induced, e.g., by calcium rises produced by back-propagating spikes (for further discussion see Chistiakova et al., 2014, The hippocampus represents a classical experimental system to study synaptic plasticity, and it has been a structure of choice for most studies of plasticity of excitatory synaptic transmission to inhibitory interneurons (Figure 1 and Table 1)

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2G), suggesting that danger signal molecules from damaged neurons lead to microglial and astrocytic activation