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Given that nausea, vomiting, diarrhea, and constipation are common adverse effects of GLP-1 medicationsparticularly during dose titrationselecting a magnesium supplement that does not exacerbate these symptoms is clinically prudent
Mechanisms of Weight Loss (The Brain and Gut) GLP-1 RAs promote weight loss through a gut-brain axis, acting on receptors in the CNS and gastrointestinal tract to regulate energy balance (Zheng et al., 2024)
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As body weight decreases, the dose of levothyroxine needed to maintain euthyroidism may change, typically requiring a reduction in thyroid hormone replacement
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