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"Dietary Vitamin D Intake, 25-Hydroxyvitamin D3 Levels and Premenstrual Syndrome in a College-Aged Population"
DES has the opposite a tripeptide deletion at the N-terminus that also reduces IGFBP binding but with different receptor-affinity profile and shorter half-life
Receptor trafficking involves the internalisation of the active receptor: Ligand complex towards endocytic compartments, followed by its deactivation/dephosphorylation and recycling back to the cell membrane, leading to its re-sensitisation, or trafficking to lysosomal organelles for its degradation and final signal termination (McGlone et al., 2021)
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