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Ethics declarations Ethics approval and consent to participate This study was performed with the approval of the Ethics Committee of Harbin Institute of Technology University and carried out in compliance with the Declaration of Helsinki of the World Medical Association

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Upon entering the nucleus, Smad4 promotes collagen synthesis through transcriptional regulation (79, 80)

[6] [7] GLP-1 receptor agonism is the mechanism shared by established medicines such as semaglutide, which is licensed in the UK as Ozempic (for type 2 diabetes) and Wegovy (for weight management)