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Alopecia is particularly common in BC patients treated with AIs, with a notable incidence among AEs ( Our analysis found positive signals for onychoclasis, vascular responses (e.g., hypersensitivity vasculitis, vascular purpura), hair abnormalities (e.g., alopecia, androgenetic alopecia, hair growth abnormality), and nail toxicity (e.g., nail disorder, discoloration, nail dystrophy) across all three AIs, indicating a need for appropriate patient care

Novel GLP-1R agonists currently under development include HRS9531, a dual GLP-1/GIP receptor agonist being evaluated in overweight or obese individuals with T2DM, which has shown promising results in a Phase 2 study [172]

Antibiotic treatment in mice (which reduced the abundance of Bacteroidetes) also reduced the expression of tight junction protein mRNA expression in the hippocampus, but increased expression in the amygdala [150]