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Oxidative stress was quantified through ROS, nitrites, TBARS, total thiols, and the activities of SOD, CAT GPx, GST, and ALA-D, using spectrophotometric assays and fluorescence-based detection

Although GLP-1 RAs by themselves have a low risk of hypoglycemia, when used in combination with sulfonylureas and/or insulin, some experts recommend lowering the dose of sulfonylureas and short-acting and low-acting pancreatic islet analogs before or during the use of GLP-1 RAs ( Corresponding to the signal intensity for weight loss poor of GLP-1 RAs in our study, a network meta-analysis showed a decreasing trend in weight loss efficacy for tirzepatide, semaglutide, and liraglutide ( 4.2 Severe versus non-severe cases The most frequently reported adverse effects associated with GLP-1 RAs were gastrointestinal in nature