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Acetaldehyde is then rapidly converted to acetic acid by aldehyde dehydrogenase (ALDH)

or Have had optimal treatment with allopurinol, however, renal impairment means that probenecid cannot be added or is likely to be ineffective Patients who have had previous Special Authority approval for benzbromarone are also eligible for Special Authority approval for febuxostat (see: Benzbromarone to be discontinued)

Both are dominated by gastrointestinal adverse events nausea, constipation, diarrhea, vomiting that are mostly mild-to-moderate and dose-related