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miR-27a-3p overexpression leads to SLC7A11 inhibition by direct binding to its 3-UTR, followed by a reduction of erastin-induced ferroptosis

These constitute a neural pathway linking the "viscero-sensory" brainstem to hypothalamic nuclei involved in energy homeostasis

While clinical translation of HAGSH scaffolds remains in its formative stage, HA-based hydrogels have already demonstrated favorable safety profiles and therapeutic efficacy in chronic ulcer management, providing a strong clinical precedent