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GLP-1 agonists like semaglutide (Ozempic) act primarily on metabolic and interoceptive systemstargeting hypothalamus, brainstem, and nucleus tractus solitariusbut they also modulate reward circuitry, including the nucleus accumbens and ventral tegmental area

Chronic excess can produce an iatrogenic acromegaly phenotype progressive soft-tissue and bone changes in hands, feet and face and contribute to hypertension and cardiac strain

Hormonal fluctuations can also boost blood flow to the face, intensifying that flushed look sometimes caused by a PCOS rash, says Dr

GH naturally declines beginning in the late 20s and accelerates after 40