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has showed that OXPHOS is positively correlated during higher viral loads among PLWH without ARVs, an indicator of disease progression ( + T cells treated with metformin, an inhibitor of mitochondrial complex I, HIV-1 replication was suppressed, but not to the extent that 2-DG suppressed replication ( The pentose phosphate pathway and HIV-1 replication The pentose phosphate pathway (PPP) plays a crucial role in maintaining cell physiology and homeostasis

AND Final approval of the version to be published

Costantini TW, Deree J, Peterson CY, et al