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Last year, medical professionals wrote about 4,000 prescriptions for semaglutidethe active ingredient in Wegovy and Ozempicfor teens ages 12 to 17

Connelly et al

October 2025, Janet Iwasa

While true pharmacological tolerance to GLP-1 receptor agonists is not well-established, tachyphylaxis of the gastric emptying effect has been documented with GLP-1 receptor agonists