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The role of CVO is crucial for sensing peripheral GLP-1 levels and relaying this information to the hypothalamus and other deep brain regions

Relevant studies have found that exendin-4 could mediate the neuroprotective effect on -aminobutyric acid neurons in the piriform cortex and striatum and play a neuroprotective role in a cAMP/PKA- and PI3K/AKT-dependent manner after stroke (84, 85)

Some patients reach their optimal dose at the second level

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