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ACSL4 and LPCAT3 are critical mediators of PUFA-PL synthesis, while arachidonate lipoxygenase (ALOX) is responsible for lipid peroxide synthesis (Doll et al., 2017

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We reported the hypothesis that CGV which supposedly should provide a maximum antioxidant function by GSH synthesis rates and concentrations as expressed by the manufacturer could act as a pro-oxidant causing oxidative damage in normal humans particularly at the supra therapeutic doses following a subchronic administration in Wistar rats