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The historical emphasis has predominantly centered on the 26S proteasome, shaping research priorities and methodologies in this area

Regarding adults, HGH has other described functions, including increasing lipolysis and lipid oxidation, which leads to mobilization of stored triglycerides, stimulation of protein synthesis that includes skeletal muscle anabolism, antagonism of insulin action that leads to glucose intolerance, and decrease of phosphate, water, and sodium renal excretion ( HGH exerts its effects through the JAK-STAT signaling pathway, influencing growth and metabolism across various tissues and organs, particularly cartilage and bone development

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