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Here are a few examples of irreversible problems of the hypothalamus and the pituitary gland (19): Pituitary tumors Tumors that compress the hypothalamus Sheehan syndrome TRH deficiency Radiation to the brain Infiltrative disorders like sarcoidosis or amyloidosis These conditions are pretty uncommon and rare compared to those we have discussed thus far but its still important to include them here

Side Effects: Unintended reactions or symptoms caused by a medication, including those possibly experienced with Semaglutide and tirzepatide

GLP-1 is necessary for standard glucose tolerance and functions through specific GLP-1Rs, which belong to the G-protein-coupled glucagon receptor family, expressed in islet -cells and stomach, small intestine, mucosa, heart, and other cell types (18, 19)

Also, lifestyle habits like smoking, consuming alcohol, too much stress, and sleepless nights worsen the situation by further lowering Glutathione levels