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This can also be seen after gall bladder removal surgery and I wonder if patients with diarrhea on retatrutide wouldnt benefit from psyllium husk fiber(aka Metamucil in the USA) or taking low doses of drugs called bile acid sequestrants until their GI can adjust to the retatrutide

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Notably, Nrxn3 , which encodes for a synaptic adhesion protein critical for maintaining synaptic function 43 , was downregulated by GIPR antagonism and GLP-1R agonism in both the C35 GABA4 and the C35 GABA3 cluster (Fig