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When the combination of sitagliptin and metformin immediate-release was coadministered with a sulfonylurea or with insulin, the percentage of patients reporting at least one adverse reaction of hypoglycemia was higher than that observed with placebo and metformin immediate-release coadministered with a sulfonylurea or with insulin (Table 3)

[3] [4] By activating GLP-1 receptors, retatrutide slows gastric emptying, reduces appetite, and enhances insulin secretion in a glucose-dependent manner

The Protocol and statistical analysis plan will be published along with the clinical outcomes of the study on www.clinicaltrials.gov