For example, the hereditary hemochromatosis factor protein is a second ligand that binds to TfR1 on a site that overlaps with that of holo-Tf on the helical and protease-like domains of the receptor
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Neurogenic inflammation in acute migraine attacks is characterized by a TVS activation-induced release of neuropeptides, such as CGRP and substance P, from trigeminal nerve fibers at the dura, which causes increased vascular permeability, plasma protein extravasation, leukocyte infiltration, vasodilation, mast cell degranulation, activation of meningeal nociceptors, and the subsequent release of inflammatory mediators (5)
