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doi: 10.1038/302716a0 88 HolstJJOrskovCNielsenOVSchwartzTW

The pipeline of next-generation treatments is advancing rapidly: Novo Nordisks CagriSema, a fixed-dose combination of semaglutide and the amylin analogue cagrilintide, has an FDA decision expected in late 2026 and could further accelerate the market

GLP-1 signaling of the significant numbers of receptors found in the lungs remains a novel target for treatment of chronic airway inflammation in asthma, with further prospective trials clearly needed to clarify the optimal population for benefit

Risk of Amputation: There is an increased risk of lower limb amputation (toes, feet) associated with empagliflozin, particularly in patients with prior amputations, peripheral vascular disease, neuropathy, and diabetic foot ulcers