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The absence of water in lyophilized peptides significantly reduces the risk of hydrolysis and microbial growth

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Usually, the portal vein of such laboratory animals does not have culturable bacteria despite the presence of systemic sepsis, suggesting that BT takes place by transfer of intestinal bacteria predominantly into the lymphatic circulation via the intestinal lymph nodes, likely via the specialized M-cells overlying lymphoid aggregates [69, 70]

These drugs are either oxidative in nature or can generate oxidant compounds in the body, inducing oxidative stress to the RBCs leading to hemolysis