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for 10 days) or vehicle, APR-017(100 mg/kg per day, ip., for 10 days), IC261(0.6 mg/kg per day, ip., for 10 days), combination therapy

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Tirzepatide exhibits a prolonged circulating half-life of approximately 120150 hours, enabling sustained receptor engagement [3]

In several animal species, for example, the drug exenatide has been able to help reduce cocaine self-administration, decrease the frequency of relapse-like behavior, and reduce dopamine release after cocaine is consumed