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A substudy of the phase 2 clinical trial specifically examined body composition changes using dual-energy X-ray absorptiometry (DEXA), the gold standard for measuring lean and fat mass

Immunohistochemical analysis demonstrated that NaBu effectively restored the reduced expression of PanKbu, H3K9bu, and p300 in the renal tissues of diabetic kidney disease (DKD) mice, with the upregulated PanKbu predominantly localized in the nucleus [42]

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Tirzepatide GLP-1 is a dual-action metabolic therapy that supports weight control by improving insulin sensitivity, reducing appetite, and enhancing satiety