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Microdosing these medications has been linked to reduced levels of pro-inflammatory cytokines like IL-6 and TNF- , which play roles in autoimmune diseases, cardiovascular risk, and aging-related decline

Furthermore, evidence indicates that GLP-1RAs inhibit inflammation in fibroblast-like synoviocytes (FLS) and attenuate RA progression [18], suggesting their potential therapeutic utility in rheumatic disorders [19]

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In addition, the low transdermal absorption rate and individual metabolic differences may affect the outcome, and it is necessary to combine scientific lifestyle intervention