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Similarly, a casecontrol study showed the correlation between plasma level of TMAO with the risk and severity of coronary heart disease (CHD) [98]

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Contraindications and Health Conditions PT-141 is not recommended for patients who: Have uncontrolled or poorly managed hypertension Are currently taking nitrate medications (due to risk of hypertensive crisis) Have a history of serious cardiovascular events (e.g., stroke, heart attack) Are pregnant, planning to become pregnant, or breastfeeding Have known hypersensitivity to bremelanotide or related peptides Additionally, patients with a history of severe allergic reactions, kidney or liver impairment, or complex neuroendocrine conditions should undergo comprehensive screening before starting PT-141

Overdose case reports describe severe toxicity (including rhabdomyolysis) at much higher self-administered doses